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A casecontrol study involving 41 AD patients and 46 healthy controls showed that hyperhomocysteinemia correlates with cognitive impairment and AD risk due to induction of cortical atrophy and reduced hippocampal activity (Nazef et al

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*A phase 1 study evaluated the pharmacokinetic profile, safety, tolerability, and immunogenicity of the doses of AJOVY tested in the phase 2 and 3 trials (225 mg and 675 mg) following single administration in healthy subjects